The Perseus Foundation

Researching Cures. Saving Lives.


Immunotherapy: background and overview
Dr. John Chretin, DVM, DACVIM, Oncology


Immunotherapy has long been regarded as the “holy grail” of cancer treatment. Its purpose is to induce or enhance an immune response and thereby boost the body’s natural defenses to fight cancer. Because of this effect, immunotherapy offers many potential advantages over traditional anti-cancer therapy such as chemotherapy. With traditional anti-cancer therapy, the goal is to directly target and effect cancer cells. Although the response rate may initially be high, the cancer inevitably mutates and acquires the ability to become resistant. With immunotherapy, the treatment is directed at the non-cancerous immune system and not the cancer itself. Hence resistance is unlikely to occur and long lasting, durable responses are possible. Studies using immunotherapeutics, have in recent times demonstrated this in both humans and animals. 
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T Cell Therapy overview

A truly heartfelt thanks to all those who participated and who donated so generously for the 

project, be it money, time or talent. We could not have achieved our goals so far without you. Words cannot adequately express how indebted we are to you.  Stay tuned, for new and exciting therapies being developed and continuing research on T Cell Therapy for Malignancies and B Cell Lymphoma.

Updated:  06.25.2017

The importance of funding translational research

T Cell Therapy Infusion at a Glance

Adoptive t Cell Immunotherapy
aurelius biotherapeutics

Adoptive T Cell Immunotherapy is a therapy that has the benefit of being able to sidestep the long-term side effects of conventional chemotherapeutic protocols.  Moreover, the modified T Cells persist in the circulation and help to guard against the cancer's recurrence.  It has the advantages of not having the toxic side-effects of standard therapy and the positive response may last for a long period of time.

The concept of treating cancer by harnessing the animal's own immune system to recognize and suppress the abnormal cells is the basis of immunotherapy.  The T Cell Therapy Protocol that we have helped developed uses this concept, and incorporates using the patient's own T Cells.  After a specific conditioning protocoll, the patient's T cells are collected and modified to enhance their recognition of the cancer cells, then grown to increase the population of the modified cells, and then infused back into the patient.  By growing the cells in the lab, we are able to enhance their ability to recognize the abnormal proteins expressed on the surface of the cancer cells.  The excess modified T cells can be frozen in order to be re-infused at a later date to boost the immune system as needed.

 



t cell therapy for b cell infusion treatment cost